Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer

da Silva, Inês V.; Mlinarić, Monika; Lourenço, Ana Rita; Pérez-Garcia, Olivia; Čipak Gašparović, Ana; Soveral, Graça (2024) Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer. International Journal of Molecular Sciences, 25 (15). ISSN 1422-0067

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Abstract

Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H2O2), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H2O2 levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H2O2 positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer.

Item Type:	Article
Uncontrolled Keywords:	aquaporin; hydrogen peroxide; membrane transport; redox signaling
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Lorena Palameta
Date Deposited:	14 Nov 2024 08:53
URI:	http://fulir.irb.hr/id/eprint/9285
DOI:	10.3390/ijms25158381

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