scCVD Diamond Membrane based Microdosimeter for Hadron Therapy

Zahradnik, Izabella A.; Pomorski, Michal T.; De Marzi, Ludovic; Tromson, Dominique; Barberet, Philippe; Skukan, Natko; Bergonzo, Philippe; Devès, Guillaume; Herault, Joël; Kada, Wataru; Pourcher, Thierry; Saada, Samuel (2018) scCVD Diamond Membrane based Microdosimeter for Hadron Therapy. physica status solidi (a), 215 (22). p. 1800383. ISSN 1862-6300

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Abstract

Hadron therapy is an innovative mode of radiotherapy (RT) for cancer treatment which enables tumour cells to be more effectively destroyed than conventional RT using photons. The precise knowledge of the lineal energy of particles is used in the field of microdosimetry (MKM model) as a fundamental parameter in the prediction of the relative biological efficiency (RBE) of clinical beams. Based on single-crystal CVD (scCVD) super-thin diamond membranes obtained using deep Ar/O plasma etching, prototypes of solid-state microdosimeters for lineal energy measurements were produced at the Diamond Sensors Laboratory of CEA-LIST. The response of a diamond membrane microdosimeter to single projectiles was investigated in ion microbeams. The microdosimeter was irradiated using a raster scanning method and the charge transport properties of the device were determined with sub-micron precision by measuring the charge collection efficiency (CCE), the µSVs 3D spatial definition and the pulse-height spectra. A prototype of this novel microdosimeter was then tested in a 100 MeV therapeutic proton beam at the Institute Curie – Proton Therapy Centre in Orsay. All results effectively demonstrate the great potential for this device to be used for studies of the RBE in clinical applications.

Item Type:	Article
Additional Information:	This research has been performed within the framework of the DIAmiDOS (Diamond membrane microdosimeter) project founded by the French Alternative Energies and Atomic Energy Commission (CEA). The authors would like to acknowledge DiamFab.eu for growing excellent quality homoepitaxial p+ diamond films. Furthermore, the authors would like to thank all collaboration partners and especially the IBIC microbeam teams in Ruder Boskovic Institute in Zagreb, Croatia and AIFIRA facility of CENBG in Bordeaux, France. This project has received funding from the European Union's Horizon 2020 Research and Innovation programme under Grant Agreement no. 654168.
Uncontrolled Keywords:	Microdosimetry; diamond microdosimeter; hadron therapy; micro-sensitive volumes; IBIC; lineal energy
Subjects:	NATURAL SCIENCES > Physics
Divisions:	Division of Experimental Physics
Projects:	Project title Project leader Project code Project type Advanced European Infrastructures for Detectors at Accelerators-AIDA-2020 UNSPECIFIED 654168 EK
Depositing User:	Stjepko Fazinić
Date Deposited:	15 Apr 2020 09:01
URI:	http://fulir.irb.hr/id/eprint/5425
DOI:	10.1002/pssa.201800383

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