Đermić, Damir (2015) Double-strand break repair mechanisms in Escherichia coli: Recent insights. Advances in Genomics and Genetics, 5 . pp. 35-42. ISSN 1179-9870
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Abstract
In order to survive all organisms must repair constantly appearing double strand breaks (DSBs) in their DNA. E. coli does it by RecA-dependent homologous recombination during which RecA protein is assembled on 3’-ended overhang that is created by a process called DNA end resection. Ensuing RecA-nucleoprotein filament searches for and invades an intact homologous DNA sequence, thus creating a central HR intermediate. This review describes recent addition to our knowledge of homologous recombination and DSB repair in E. coli, especially the processes that precede the formation of a RecA-nucleoprotein filament, with the emphasis on the regulation of the 3’-tail metabolism. Since homologous recombination is a highly conserved process, the parallels to DSB repair in eukaryotic systems are discussed bearing in mind that the lessons learnt from the studies in simpler, bacterial models may be useful for studying DSB repair and maintenance of genome stability in eukaryotes.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | RecA-nucleoprotein filament; homologous recombination; exonucleases; genome stability; 3’- overhang metabolism | ||||||||
| Subjects: | NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology NATURAL SCIENCES > Biology > Microbiology NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Damir Đermić | ||||||||
| Date Deposited: | 05 May 2015 11:56 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/1813 | ||||||||
| DOI: | 10.2147/AGG.S51699 |
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