TEX264 at the intersection of autophagy and DNA repair

Popović, Marta (2022) TEX264 at the intersection of autophagy and DNA repair. Autophagy, 18 (1). pp. 40-49. ISSN 1554-8627

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Abstract

TEX264 (testes expressed gene 264) is a single pass transmembrane protein, consisting of an N-terminal hydrophobic region, a gyrase inhibitory (GyrI)-like domain, and a loosely structured C terminus. TEX264 was first identified as an endoplasmic reticulum (ER)-resident Atg8-family binding protein that mediates the degradation of portions of the ER during starvation (i.e., reticulophagy). More recently, TEX264 was identified as a cofactor of VCP/p97 ATPase that promotes the repair of covalently trapped TOP1 (DNA topoisomerase 1)-DNA crosslinks. This review summarizes the current knowledge of TEX264 as a protein with roles in both autophagy and DNA repair and provides an evolutionary and structural analysis of GyrI proteins. Based on our phylogenetic analysis, we provide evidence that TEX264 is a member of a large superfamily of GyrI-like proteins that evolved in bacteria and are present in metazoans, including invertebrates and chordates.

Item Type:	Article
Uncontrolled Keywords:	Autophagy; DNA repair; gyrase inhibitory-like proteins; nucleophagy; reticulophagy; TEX264
Subjects:	NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Human Genetics, Genomics and Proteomics
Divisions:	Division for Marine and Enviromental Research
Projects:	Project title Project leader Project code Project type Razumijevanje popravka unakrsnog vezanja DNA-Protein in vivo koristeći zebricu kao istraživački model-DNAPRO Marta Popović UIP-2017-05-5258 HRZZ Strukturna karakterizacija faktora uključenih u popravak unakrsnog vezanja DNA-protein- Marta Popović IPS-2020-01-4225 HRZZ STIM-REI-STIM-REI Vlasta Bonačić-Koutecky; Tvrtko Smital; Sandi Orlić; Ante Bilušić; Mile Dželalija; Damir Kovačić; Darko Koračin; Željka Sanader Maršić KK.01.1.1.01.0003 EK Medical Council Research Programme grant MC_PC_12001/1 Kristijan Ramadan MC_PC_12001/1 MRC Medical Council Research Programme grant MC_UU_00001/1 Kristijan Ramadan MC_UU_00001/1 MRC
Depositing User:	Marta Popović
Date Deposited:	06 Feb 2024 13:54
URI:	http://fulir.irb.hr/id/eprint/8456
DOI:	10.1080/15548627.2021.1894059

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