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Double-strand break repair mechanisms in Escherichia coli: Recent insights

Đermić, Damir (2015) Double-strand break repair mechanisms in Escherichia coli: Recent insights. Advances in Genomics and Genetics, 5 . pp. 35-42. ISSN 1179-9870

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In order to survive all organisms must repair constantly appearing double strand breaks (DSBs) in their DNA. E. coli does it by RecA-dependent homologous recombination during which RecA protein is assembled on 3’-ended overhang that is created by a process called DNA end resection. Ensuing RecA-nucleoprotein filament searches for and invades an intact homologous DNA sequence, thus creating a central HR intermediate. This review describes recent addition to our knowledge of homologous recombination and DSB repair in E. coli, especially the processes that precede the formation of a RecA-nucleoprotein filament, with the emphasis on the regulation of the 3’-tail metabolism. Since homologous recombination is a highly conserved process, the parallels to DSB repair in eukaryotic systems are discussed bearing in mind that the lessons learnt from the studies in simpler, bacterial models may be useful for studying DSB repair and maintenance of genome stability in eukaryotes.

Item Type: Article
Uncontrolled Keywords: RecA-nucleoprotein filament; homologous recombination; exonucleases; genome stability; 3’- overhang metabolism
Subjects: NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
NATURAL SCIENCES > Biology > Microbiology
NATURAL SCIENCES > Biology > Genetics, Evolution and Phylogenetics
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Molekularni mehanizmi rekombinacije i popravka DNA[183775] Davor Zahradka098-0982913-2862MZOS
Depositing User: Damir Đermić
Date Deposited: 05 May 2015 11:56
DOI: 10.2147/AGG.S51699

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