Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular Disorders

Zlendić, Marko; Vrbanović Đuričić, Ema; Gall Trošelj, Koraljka; Tomljanović, Marko; Vuković Đerfi, Kristina; Alajbeg, Iva Z. (2024) Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular Disorders. International Journal of Molecular Sciences, 25 (16). ISSN 1422-0067

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Abstract

This case-control study investigated single nucleotide polymorphism (SNP) genotypes (CXC motif chemokine ligand 8 (CXCL8): rs2227306 and rs2227307 and tumor necrosis factor (TNF): rs1800629) in 85 patients with pain-related temporomandibular disorders (TMDp) and 85 controls to explore their associations with TMDp presence, pain intensity (low/high), and the presence of chronic arthralgia/myalgia. TMDp was diagnosed using a validated protocol, and polymorphisms were genotyped from buccal mucosa swabs using TaqMan assays. High pain intensity individuals had an increased risk for carrying minor allele “G” (rs2227307) and “T” (rs2227306) compared to controls (76% vs. 55.3%, p = 0.012; 72% vs. 54.1%, p = 0.030, respectively). Carriers of the minor allele “G” (rs2227307) were more prevalent in TMDp patients with arthralgia compared to controls (70.30% vs. 55.30%, p = 0.037). According to logistic regression, the most important predictors for high pain intensity were minor allele “G” of rs2227307 (OR 2.435, 95% CI 1.123–5.282), increasing age (OR 1.038, 95% CI 1.002–1.075), and female sex (OR 4.592, 95% CI 1.289–16.361). The explored gene polymorphisms were not significant risk factors for TMDp presence. These findings highlight the importance of genetic variations, particularly rs2227307, in understanding the diverse clinical manifestations of temporomandibular disorders.

Item Type:	Article
Uncontrolled Keywords:	inflammation; cytokines; interleukin-8; single nucleotide polymorphism; chronic pain; temporomandibular disorders
Subjects:	BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Dental Medicine
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Povezanost genskih polimorfizama s temporomandibularnim poremećajima-GenPolTMD Iva Alajbeg; Ema Vrbanović; Zlatko Dembić; Lea Vuletić; Ivan Alajbeg; Senka Meštrović; Ivana Lapić; Dijana Zadravec; Davor Illeš IP-2019-04-6211 HRZZ Functional association of gene activity and sensory perception with painful temporomandibular disorders UNSPECIFIED IP-2024-05-7019 HRZZ
Depositing User:	Ivana Vuglec
Date Deposited:	13 Oct 2025 08:32
URI:	http://fulir.irb.hr/id/eprint/9989
DOI:	10.3390/ijms25168730

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