Miletić, Marija; Markeljević, Jasenka; Glavina, Ana; Sabol, Ivan; Vukosav, Vinka; Mrsić, Fanika; Barić, Anastasija; Mravak-Stipetić, Marinka (2021) Correlation of clinical and histopathological findings in patients with clinically suspected primary Sjögren syndrome. Reumatizam, 68 (1). pp. 1-13. ISSN 2459-6159
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Abstract
Introduction. association of clinical and diagnostic findings is important in making correct diagnosis in patients with primary sjogren’s syndrome. The aim of this study was to evaluate the correlation of minor salivary gland biopsy, serological findings and sialometry, as components used to classify primary sjögren’s syndrome. Materials and methods. Thirty-six patients with subjective symptoms of possible primary sjögren’s syndrome underwent minor salivary gland biopsy and sialometry. Clinical and laboratory data were retrieved from the clinical files. We compared and correlated biopsy results, serological findings and salivary flow rate between sjögren and non-sjögren patients. Patients were classified into two groups, twenty-eight cases (77.8%) had a diagnosis of primary sjögren’s syndrome and eight cases (22.2%) did not fulfill the classification criteria for diagnosis. Results. Primary sjögren’s syndrome diagnosis strongly correlated with “positive” biopsy (rho= 0.93, p<0.001), serological findings (rho= 0.38, p=0.023) and negatively correlated with saliva flow rate (rho= –0.51, p=0.002). “Positive” biopsy results were in negative correlation with saliva flow rate (rho= –0.41, p=0.012), but in a stronger correlation with patients below the diagnostic flow rate cutoff (≤0.1ml/minute, rho= 0.46, p=0.005). Conclusion. in conclusion, unstimulated whole salivary flow rate ≤0.1 ml/minute is highly predictive of “positive” biopsy and can be used as a supplemental method to biopsy in diagnosing the oral component of primary sjögren’s syndrome.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | Sjögren’s syndrome; sialometry; salivary; gland; biopsy; classification | ||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Immunology BIOMEDICINE AND HEALTHCARE > Dental Medicine > Oral Medicine |
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| Divisions: | Division of Molecular Medicine | ||||||||
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| Depositing User: | Ivan Sabol | ||||||||
| Date Deposited: | 05 Sep 2025 08:05 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/9968 | ||||||||
| DOI: | 10.33004/reumatizam-68-1-1 |
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