Rapid and Green Anion-Assisted Mechanochemical Peptide Cyclization

Duvnjak, Mirko; Vidović, Nikolina; Užarević, Krunoslav; Horvat, Gordan; Tomišić, Vladislav; Speranza, Giovanna; Cindro, Nikola (2025) Rapid and Green Anion-Assisted Mechanochemical Peptide Cyclization. ACS Sustainable Chemistry & Engineering, 13 (1). pp. 30-35. ISSN 2168-0485

PDF - Published Version - article Available under License Creative Commons Attribution. Download (2MB)

Abstract

A novel mechanochemical approach is described for chloride-templated head-to-tail macrocyclization of a pentapeptide and a hexapeptide. This straightforward method allows the solvent-free preparation of cyclopeptides with yields comparable to solution-based approaches without the need for high dilution of the reaction mixture and with significantly reduced reaction times and organic waste amount.

Item Type:	Article
Uncontrolled Keywords:	ball-milling; cyclization; green chemistry; peptides and proteins; solvent-free
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEM Krunoslav Užarević IP-2020-02-4702 HRZZ Koordinacijske reakcije makrocikličkih liganada u otopini-MacroSol Vladislav Tomišić IP-2019-04-9560 HRZZ Totalna sinteza bioaktivnih metabolita – Od dubokomorskih mikroorganizama do nove klase antibiotika i sintetskih metodologija (ToSiAn) Nikola Cindro NPOO.C3.2.R2-I1.06.0043 EU
Depositing User:	Ana Zečević
Date Deposited:	02 May 2025 09:40
URI:	http://fulir.irb.hr/id/eprint/9798
DOI:	10.1021/acssuschemeng.4c03309

Actions (login required)

View Item