Feliciello, Isidoro; Ugarković, Đurđica (2023) Alpha Satellite DNA in Targeted Drug Therapy for Prostate Cancer. International Journal of Molecular Sciences, 24 (21). ISSN 1422-0067
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Abstract
Prostate cancer is the most common solid cancer in men and, despite the development of many new therapies, metastatic castration-resistant prostate cancer still remains a deadly disease. Therefore, novel concepts for the treatment of metastatic prostate cancer are needed. In our opinion, the role of the non-coding part of the genome, satellite DNA in particular, has been underestimated in relation to diseases such as cancer. Here, we hypothesise that this part of the genome should be considered as a potential target for the development of new drugs. Specifically, we propose a novel concept directed at the possible treatment of metastatic prostate cancer that is mostly based on epigenetics. Namely, metastatic prostate cancer is characterized by the strongly induced transcription of alpha satellite DNA located in pericentromeric heterochromatin and, according to our hypothesis, the stable controlled transcription of satellite DNA might be important in terms of the control of disease development. This can be primarily achieved through the epigenetic regulation of pericentromeric heterochromatin by using specific enzymes as well as their activators/inhibitors that could act as potential anti-prostate cancer drugs. We believe that our concept is innovative and should be considered in the potential treatment of prostate cancer in combination with other more conventional therapies.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | metastatic prostate cancer; satellite DNA; heterochromatin; epigenetics; histone modification; transcription; anti-prostate cancer drugs | ||||||||
| Subjects: | NATURAL SCIENCES > Biology | ||||||||
| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Lorena Palameta | ||||||||
| Date Deposited: | 15 Apr 2025 13:40 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/9697 | ||||||||
| DOI: | 10.3390/ijms242115585 |
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