Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

Borović Šunjić, Suzana; Jaganjac, Morana; Vlainić, Josipa; Halasz, Mirna; Žarković, Neven (2024) Lipid Peroxidation-Related Redox Signaling in Osteosarcoma. International Journal of Molecular Sciences, 25 (8). ISSN 1422-0067

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Abstract

Oxidative stress and lipid peroxidation play important roles in numerous physiological and pathological processes, while the bioactive products of lipid peroxidation, lipid hydroperoxides and reactive aldehydes, act as important mediators of redox signaling in normal and malignant cells. Many types of cancer, including osteosarcoma, express altered redox signaling pathways. Such redox signaling pathways protect cancer cells from the cytotoxic effects of oxidative stress, thus supporting malignant transformation, and eventually from cytotoxic anticancer therapies associated with oxidative stress. In this review, we aim to explore the status of lipid peroxidation in osteosarcoma and highlight the involvement of lipid peroxidation products in redox signaling pathways, including the involvement of lipid peroxidation in osteosarcoma therapies.

Item Type:	Article
Uncontrolled Keywords:	lipid peroxidation; reactive aldehydes; redox signaling; osteosarcoma
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Lorena Palameta
Date Deposited:	29 Oct 2024 12:48
URI:	http://fulir.irb.hr/id/eprint/9217
DOI:	10.3390/ijms25084559

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