Editorial: Curcuminoids: their pleiotropism against hallmarks of cancers

Pouliquen, Daniel L.; Gall Trošelj, Koraljka; Anto, Ruby John; Naidu, Rakesh (2023) Editorial: Curcuminoids: their pleiotropism against hallmarks of cancers. Frontiers in Pharmacology, 14 . ISSN 1663-9812

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Abstract

Curcuminoids (natural and synthetic diarylheptanoids) represent a growing topic in cancer research, with 5,562 references reported in the Pubmed database since 1983. During the past two decades, the number of annually published articles has been continuously raising, reaching more than 450 papers per year between 2018 and 2021, and including more than 80 annual reviews. A wealth of studies has documented pleiotropic effects of curcumin against hallmarks of cancers both in vitro and in vivo, and new analogs, formulations, and innovative nanomaterials offering improved bioactivity, in addition to its historical leading molecule, curcumin, are currently under development (Lu et al., 2023). Therefore, this Research Topic aimed at providing an updated overview of some aspects of this research, highlighting the complexity of their mechanisms of action, and addressing several important questions that are relevant for a potential future translation of experimental data into clinical studies.

Item Type:	Article
Uncontrolled Keywords:	curcuminoids; cancer; response to therapy; curcumin; curcumin analogs; molecular targets; signaling pathways; nano-formulations; molecular mechanism; clinical trials; combined therapy
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Depositing User:	Diana Mikoč Radešić
Date Deposited:	30 Aug 2024 09:40
URI:	http://fulir.irb.hr/id/eprint/9036
DOI:	10.3389/fphar.2023.1266793

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