Leović, Matko; Jakovčević, Antonija; Mumlek, Ivan; Zagorac, Irena; Sabol, Maja; Leović, Dinko (2024) A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma. International Journal of Molecular Sciences, 25 (9). ISSN 1422-0067
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Abstract
Tumors of the head and neck, more specifically the squamous cell carcinoma, often show upreg-ulation of the Hedgehog signaling pathway. However, almost nothing is known about its role in the sinonasal adenocarcinoma, either in intestinal nor non-intestinal subtypes. In this work, we have analyzed immunohistochemical staining of six Hedgehog pathway proteins: SHH, IHH, PTCH1, GLI1, GLI2 and GLI3, on 21 samples of sinonasal adenocarcinoma, and compared them with six colon adenocarcinoma and three salivary gland tumors, as well as with matching healthy tissue, where available. We have detected GLI2 and PTCH1 in the majority of samples, and also GLI1 in a subset of samples, while GLI3 and the ligands SHH and IHH were generally not detected. PTCH1 pattern of staining shows an interesting pattern, where healthy samples are mostly posi-tive in the stromal compartment, while the signal shifts to the tumor compartment in tumors. This, taken together with a stronger signal of GLI2 in tumors compared to non-tumor tissues, suggests that Hedgehog pathway is indeed activated in sinonasal adenocarcinoma. As Hedgehog pathway inhibitors are being tested in combination with other therapies for head and neck squamous cell carcinoma, this could provide a therapeutic option for patients with sinonasal adenocarcinoma as well.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | Hedgehog ; sinonasal adenocarcinoma ; tumor-stroma interaction | ||||||||
| Subjects: | NATURAL SCIENCES BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences |
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| Divisions: | Division of Molecular Medicine | ||||||||
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| Depositing User: | Ana Zečević | ||||||||
| Date Deposited: | 23 Jul 2024 07:39 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/8965 | ||||||||
| DOI: | 10.3390/ijms25094630 |
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