Lončarić, Marija (2024) Talin and KANK proteins in integrin αVβ5 mediated focal and reticular adhesions in melanoma cell line MDA-MB-435S. Doctoral thesis, Institut Ruđer Bošković.
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Abstract
Melanoma cell line MDA-MB-435S forms integrin αVβ5 mediated focal (FA) and reticular adhesions (RA). Knockdown of integrin αV increases the sensitivity of MDA-MB-435S cells to the microtubule-targeting antitumor drug paclitaxel and reduces migration. In this work, we showed that the mechanism of these effects is mediated by the binding of talin 2 from FA and KANK2 from the cortical microtubule stabilizing complex. We identified talin 2 as a potential target in tumor therapy. We analyzed RA in MDA-MB-435S cells and discovered KANK2 as a new component of RA.
| Item Type: | Thesis (Doctoral thesis) | ||||||||
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| Uncontrolled Keywords: | Focal Adhesion; Reticular Adhesion; Talin; KANK; Paclitaxel; Melanoma | ||||||||
| Subjects: | NATURAL SCIENCES > Biology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Marija Lončarić | ||||||||
| Date Deposited: | 09 Jul 2024 12:55 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/8923 |
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