Monitoring HPV Prevalence and Risk Cofactors for Abnormal Cytology in the Post-Vaccination Period among Croatian Women

Pešut, Ena; Šimić, Ivana; Fureš, Rajko; Milutin Gašperov, Nina; Lež, Cvjetko; Feratović, Fabijan; Kukina Žvigač, Tomica; Grce, Magdalena; Erceg Ivkošić, Ivana; Sabol, Ivan (2024) Monitoring HPV Prevalence and Risk Cofactors for Abnormal Cytology in the Post-Vaccination Period among Croatian Women. Viruses, 16 (4). ISSN 1999-4915

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Abstract

The incidence and mortality rate of cervical cancer in Croatia remains a health challenge despite screening efforts. Besides the persistent infection with HPV, the development of cancer is also associated with some cofactors. The goal of this study was to assess circulating HPV genotypes and risk factors for the development of cervical precancer after almost 16 years from the onset of HPV vaccination in Croatia. In this study, a total of 321 women attending gynecological care were evaluated. Relevant medical and demographic information, including cytology, were collected. HPV genotyping was performed by PCR. Comparing the HPV types found in circulation in the pre-vaccination (1999–2015) and post-vaccination periods (2020–2023), a statistically significant reduction in HPV 31 was noted, while the overall prevalence increased in the post-vaccination period. Besides the expected HPV positivity as a risk factor, the history of smoking was associated with LSIL or worse cytology at enrollment. For the first time, this population study revealed a statistically significant shift in the HPV genotype in the post-vaccination period, as well as the confirmation of risk factors for the development of abnormal cytology among Croatian women.

Item Type:	Article
Uncontrolled Keywords:	HPV; cervical cancer; prevalence; screening; vaccination
Subjects:	BIOMEDICINE AND HEALTHCARE > Public Health and Health Care > Epidemiology
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Multifaktorna analiza HPV inficiranih stanica u nastanku raka vrata maternice-MACCD Ivan Sabol; Ivana Erceg Ivkošić; Rajko Fureš; Tomaš Kalina; Branka Molnar Stantić IP-2019-04-3403 HRZZ
Depositing User:	Ivan Sabol
Date Deposited:	19 Jun 2024 13:44
URI:	http://fulir.irb.hr/id/eprint/8903
DOI:	10.3390/v16040642

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