Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD

Domitrovic Spudic, Sandra; Nikolac Perković, Matea; Uzun, Suzan; Nedić Erjavec, Gordana; Kozumplik, Oliver; Švob Štrac, Dubravka; Mimica, Ninoslav; Pivac, Nela (2022) Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD. Psychiatry Research, 316 . ISSN 0165-1781

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Abstract

Post-traumatic stress disorder (PTSD) is a trauma and stress related disorder frequently associated with cognitive decline. War veterans with PTSD have a higher risk of developing dementia than healthy subjects. Brain derived neurotrophic factor (BDNF) is an important protein that modulates plasticity, memory consolidation and cognitive processes. Lower circulating BDNF levels were related to memory impairment and cognitive deterioration. The aim of this study was to evaluate cognitive deterioration and plasma BDNF concentration in 120 veterans with combat related PTSD, 120 healthy controls, 47 subjects with mild cognitive impairment (MCI) and 76 patients with Alzheimer's disease (AD), and to assess if plasma BDNF concentration might be used as biomarker of cognitive deterioration. Veterans with PTSD had significantly decreased plasma BDNF concentration and worse cognitive performances (assessed using the Mini Mental State Examination, Clock Drawing test and Montreal Cognitive Assessment scores/categories) than healthy subjects, and similarly reduced plasma BDNF and cognitive decline as MCI subjects. Reduced plasma BDNF was found in cognitively impaired subjects. These results suggest that veterans with PTSD should be closely monitored in order to early detect and predict cognitive worsening and promote interventions that might help restore blood BDNF levels and cognitive functions.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer's disease ; Brain-derived neurotrophic factor ; Cognition ; Mild cognitive impairment ; Post-traumatic stress disorder ; Veterans
Subjects:	BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Terapijski potencijal neurosteroida i neurotrofina u demenciji-TePoNeDe Dubravka Švob Štrac; Ninoslav Mimica; Suzana Uzun; Oliver Kozumplik; Julija Erhardt; Ana-Marija Domijan; Dora Zelena; Erika Pinter; Coral Barbas IP-2019-04-6100 HRZZ
Depositing User:	Matea Nikolac Perković
Date Deposited:	08 Feb 2024 11:57
URI:	http://fulir.irb.hr/id/eprint/8553
DOI:	10.1016/j.psychres.2022.114772

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