Majhen, Dragomira (2022) Human adenovirus type 26 basic biology and its usage as vaccine vector. Reviews in Medical Virology, 32 (6). ISSN 1052-9276
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Abstract
Due to their nature, adenoviruses have been recognised as promising candidates for vaccine vector development. Since they mimic natural infection, recombinant adenovirus vectors have been proven as ideal shuttles to deliver foreign transgenes aiming at inducing both humoral and cellular immune response. In addition, a potent adjuvant effect can be exerted due to the adenovirus inherent stimulation of various elements of innate and adaptive immunity. Due to its low seroprevalence in humans as well as induction of favourable immune response to inserted transgene, human adenovirus type 26 (HAdV-D26) has been recognised as a promising platform for vaccine vector development and is studied in number of completed or ongoing clinical studies. Very recently HAdV-D26 based Ebola and Covid-19 vaccines were approved for medical use. In this review, current state of the art regarding HAdV-D26 basic biology and its usage as vaccine vector will be discussed.
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| Additional Information: | "This is the peer reviewed version of the following article: Majhen, Dragomira (2022) Human adenovirus type 26 basic biology and its usage as vaccine vector. Reviews in Medical Virology, 32 (6). ISSN 1052-9276which has been published in final form at http://doi.org/10.1002/rmv.2338 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." | ||||||||
| Uncontrolled Keywords: | adenovirus; adenovirus type 26; vaccination; vaccine vector; virus vector | ||||||||
| Subjects: | NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology NATURAL SCIENCES > Biology > Microbiology |
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| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Dragomira Majhen | ||||||||
| Date Deposited: | 05 Feb 2024 14:44 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/8437 | ||||||||
| DOI: | 10.1002/rmv.2338 |
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