Hh-Gli signaling pathway functions and its therapeutic potential in cancer

Levanat, Sonja; Sabol, Maja; Musani, Vesna (2008) Hh-Gli signaling pathway functions and its therapeutic potential in cancer. Croatica Chemica Acta, 81 (1). pp. 1-5. ISSN 0011-1643

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Abstract

Hh-Gli signaling pathway is one of the major and highly conserved pathways regulating embryogenesis and organ development. Its aberrant functioning is associated with malformations and cancer. Major proteins involved in the pathway are Hh, Ptch, Smo, and Gli1. Recent discoveries showed that the pathway is involved in many common and lethal tumors, such as breast, lung, prostate and digestive tract cancer. In these cases, tumor growth appears to require abnormal Hh stimulation from the surrounding cells, which causes a strong intracellular response of the pathway. Extensive involvement of the Hh-Gli pathway in tumor development has promoted it into an important target for cancer therapy, by discovery of a small molecule, cyclo-pamine, which was shown to block Smo. Successful tumor growth inhibition was accomplished both in cell cultures and on animal models. Current research includes analogous molecules, and alternative strategies of intervention on the other elements of the Hh-Gli pathway.

Item Type:	Article
Uncontrolled Keywords:	Hh-Gli signaling pathway; cancer; development; therapy; small-molecule inhibitor; basal-cell carcinoma; sonic-hedgehog; pancreatic-cancer; ovarian dermoids; growth; expression; gene; medulloblastoma; proliferation
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije [113154] Sonja Levanat 098-0982464-2461 MZOS
Depositing User:	Sonja Levanat
Date Deposited:	24 Oct 2013 14:22
URI:	http://fulir.irb.hr/id/eprint/838

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