Čorak, Nina
(2022)
Differential expression and evolutionary signatures of Borrelia burgdorferi morphotypes.
Doctoral thesis, Institute Ruđer Bošković.
Abstract
In laboratory conditions, Borrelia burgdorferi, the causative agent of Lyme disease, exists as a spirochete, round body, bleb, or biofilm culture. This doctoral thesis suggests that spirochete to round body transition relies on the delicate regulation of a relatively small number of evolutionary conserved genes. In contrast, spirochete to bleb and biofilm transition includes significant reshaping of transcription profiles towards evolutionary young genes.
| Item Type: |
Thesis
(Doctoral thesis)
|
| Uncontrolled Keywords: |
Borrelia burgdorferi ; Lyme disease ; Differential expression ; Bacterial morphotypes ; Morphological plasticity ;Genomic phylostratigraphy |
| Subjects: |
NATURAL SCIENCES > Biology > Microbiology |
| Divisions: |
Division of Molecular Biology |
| Projects: |
| Project title | Project leader | Project code | Project type |
|---|
| Filostratigrafija nastanka i gubitka gena-PhyLoss | Tomislav Domazet-Lošo | IP-2016-06-5924 | HRZZ |
|
| Depositing User: |
Nina Čorak
|
| Date Deposited: |
05 Oct 2022 08:23 |
| URI: |
http://fulir.irb.hr/id/eprint/7544 |
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