Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes

Kurutos, Atanas; Orehovec, Iva; Saftić, Dijana; Horvat, Lucija; Crnolatac, Ivo; Piantanida, Ivo; Deligeorgiev, Todor (2018) Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes. Dyes and Pigments, 158 . pp. 517-525. ISSN 0143-7208

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Abstract

We have prepared new series of lipophilic cyanine dyes equipped with several cationic quaternary ammonium moieties. This was achieved by introducing DABCO within the structures. Furthermore, to investigate the influence of the additional cationic charges on the cellular uptake, DABCO was quaternized with methyl group or alkyl piperidine cation. Spectroscopic and isothermal titration calorimetry studies as well as MTT assay and subcellular localization using confocal laser scanning microscopy revealed that some of the presented dyes combine low anti-proliferative effect with efficient cellular uptake, high affinity towards ds-DNA/RNA and remarkable fluorescent marking of mitochondria.

Item Type:	Article
Uncontrolled Keywords:	cyanine ; DABCO ; mitochondria ; fluorescence ; confocal microscopy
Subjects:	NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Višenamjensko očitavanje DNA/RNA sekundarne strukture molekularnim kemijskim senzorima-DNA/RNA-MolSense Ivo Piantanida; Carsten Schmuck; Tamara Šmidlehner IP-2013-11-1477 HRZZ
Depositing User:	Dijana Pavlović Saftić
Date Deposited:	02 Sep 2022 11:40
URI:	http://fulir.irb.hr/id/eprint/7536
DOI:	10.1016/j.dyepig.2018.05.035

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