Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina

Baković, Petra (2021) Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina. Doctoral thesis, Institut Ruđer Bošković.

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Abstract

Maintenance of energy balance is a complex physiological function, dysregulation of which can lead to obesity and metabolic disorders such as diabetes. Here, we aimed to contribute to a better understanding of the role of serotonin (5HT) in the mechanisms regulating energy homeostasis, by using sublines of rats with constitutionally increased (5HT-high) or decreased (5HT-low) activity of 5HT. Animals from both sublines were subjected to a high-calorie, high-fat diet and compared for their functional and molecular response to this metabolic challenge. Consistent with previous findings, when administered conventional diet, animals from the 5HT-high subline had poorer metabolic health than animals from 5HT-low subline. However, in response to a high-fat diet, 5HT-low animals showed a greater tendency to gain weight, poorer glycemic control, higher development of insulin resistance, and more pronounced changes in the expression of various metabolic genes in the hypothalamus and adipose tissue. The obtained results suggest that constitutionally decreased activity of 5HT is associated with a higher susceptibility to adverse effects of a high-calorie diet.

Item Type:

Thesis (Doctoral thesis)

Uncontrolled Keywords:

obesity; serotonin; high-fat diet; animal model; Wistar-Zagreb 5HT rat

Subjects:

NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology

Divisions:

Division of Molecular Biology

Projects: