Coronary collateralization prevents myocardial ROS surge induced by revascularization after non–ST-elevation acute coronary syndrome: A pilot study

Marinović, Jasna; Mihanović, Ivan; Maltar-Strmečki, Nadica; Bulat, Cristijan; Zanchi, Jaksa; Ljubković, Marko (2021) Coronary collateralization prevents myocardial ROS surge induced by revascularization after non–ST-elevation acute coronary syndrome: A pilot study. Progress in Cardiovascular Diseases, 68 . pp. 99-101. ISSN 0033-0620

| Request a personal copy from author

Abstract

Revascularization therapies are essential for efficient treatment of acute coronary syndrome. Yet, besides rescuing the affected myocardium from excessive damage, reperfusion also inflicts additional injury. In this study, we assessed levels of reactive oxygen species (ROS), the main culprits of reperfusion injury, in myocardium of patients undergoing revascularization after acute coronary syndrome. We found that revascularization by coronary artery bypass grafting after non-ST elevation acute coronary syndrome is associated with significant increase in ROS levels in patients without developed coronary artery collaterals, but patients with collateralization exhibit no such effect of reperfusion. This demonstrates protective effect of coronary artery collateralization and re-iterates the vulnerability of patients without collaterals, making them most appropriate candidates for cardioprotective interventions targeting the reperfusion injury.

Item Type:	Article
Uncontrolled Keywords:	reperfusion injury ; mitochondria ; reactive oxygen species ; acute coronary syndrome
Subjects:	NATURAL SCIENCES > Physics NATURAL SCIENCES > Chemistry BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Surgery BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Pathophysiology BIOMEDICINE AND HEALTHCARE > Public Health and Health Care
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Proučavanje reperfuzijske ozljede u ljudskom srcu; sprječavanje negativnih aspekata vitalnog terapeutskog postupka Ljubković, Marko IP-2016-06-6153 HRZZ
Depositing User:	Nadica Maltar Strmečki
Date Deposited:	13 Dec 2021 14:35
URI:	http://fulir.irb.hr/id/eprint/6804
DOI:	10.1016/j.pcad.2021.09.005

Actions (login required)

View Item