Mitotic spindle: lessons from theoretical modeling

Tolić, Iva Marija; Pavin, Nenad (2021) Mitotic spindle: lessons from theoretical modeling. Molecular Biology of the Cell, 32 (3). pp. 218-222. ISSN 1059-1524

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Abstract

Cell biology is immensely complex. To understand how cells work, we try to find patterns and suggest hypotheses to identify underlying mechanisms. However, it is not always easy to create a coherent picture from a huge amount of experimental data on biological systems, where the main players have multiple interactions or act in redundant pathways. In such situations, when a hypothesis does not lead to a conclusion in a direct way, theoretical modeling is a powerful tool because it allows us to formulate hypotheses in a quantitative manner and understand their consequences. A successful model should not only reproduce the basic features of the system but also provide exciting predictions, motivating new experiments. Much is learned when a model based on generally accepted knowledge cannot explain experiments of interest, as this indicates that the original hypothesis needs to be revised. In this Perspective, we discuss these points using our experiences in combining experiments with theory in the field of mitotic spindle mechanics.

Item Type:	Article
Uncontrolled Keywords:	mitotic spindle ; microtubules ; kinetochores ; kinetochore fibers ; bridging fibers ; kinesins ; forces ; laser ablation ; microneedle ; theory ; modeling
Subjects:	NATURAL SCIENCES > Physics > Biophysics and Medical Physics NATURAL SCIENCES > Biology NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Molecular origins of aneuploidies in healthy and diseased human tissues-ANEUPLOIDY Iva Tolić; Nenad Pavin 855158 EK Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena-SpindleForm Iva Tolić PZS-2019-02-7653 HRZZ Ravnoteža sila i momenta sila u diobenom vretenu-SpindleForceBalance Nenad Pavin IP-2019-04-5967 HRZZ Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri-QuantiXLie Hrvoje Buljan; Pavle Pandžić KK.01.1.1.01.0004 EK A new class of microtubules in the spindle exerting forces on kinetochores-NewSpindleForce Iva Tolić 647077 EK
Depositing User:	Maša Sabo
Date Deposited:	21 May 2021 10:29
URI:	http://fulir.irb.hr/id/eprint/6399
DOI:	10.1091/mbc.e20-05-0335

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