Fornasaro, Stefano; Alsamad, Fatima; Baia, Monica; de Carvalho, Luís A.E. Batista; Beleites, Claudia; Byrne, Hugh J.; Chiado, Alessandro; Chis, Michaela; Chisanga, Malama; Daniel, Amuthachelvi; Dybas, Jakub; Eppe, Gauthier; Falgayrac, Guillaume; Faulds, Karen; Gebavi, Hrvoje; Giorgis, Fabrizio; Goodacre, Royston; La Manna, Pietro; Laing, Stacey; Litti, Lucio; Lyng, Fiona M.; Malek, Kamilla; Malherbe, Cedric; Marques, Maria P. M.; Meneghetti, Moreno; Mitri, Elisa; Mohaček Grošev, Vlasta; Morasso, Carlo Francesco; Muhamadali, Howbeer; Musto, Pellegrino; Novara, Chiara; Pannico, Marianna; Penel, Guillaume; Piot, Olivier; Rindzevicius, Tomas; Rusu, Elena A.; Michael S., Michael; Sergo, Valter; Sockalingum, Ganesh D.; Untereiner, Valérie; Vanna, Renzo; Wiercigroch, Ewelina; Bonifacio, Alois (2020) Surface Enhanced Raman Spectroscopy for quantitative analysis: results of a large-scale European multi-instrument interlaboratory study. Analytical Chemistry, 92 (5). pp. 4053-4064. ISSN 0003-2700
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Abstract
Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint signals of molecules and for the investigation of a series of surface chemical reactions. Many studies introduced quantitative applications of SERS in various fields, and several SERS methods have been implemented for each specific application, ranging in performance characteristics, analytes used, instruments, and analytical matrices. Ingeneral, very few methods have been validated according tointernational guidelines. As a consequence, the application of SERS in highly regulated environments is still considered risky, and theperception of a poorly reproducible and insufficiently robust analytical technique has persistently retarded its routineimplementation. Collaborative trials are a type of interlaboratory study (ILS) frequently performed to ascertain the quality of a single analytical method. The idea of an ILS of quantification with SERS arose within the framework of Working Group 1 (WG1) of the EU COST Action BM1401 Raman4Clinics in an effort to overcome the problematic perception of quantitative SERS methods. Here, we report the first interlaboratory SERS study ever conducted, involving 15 laboratories and 44 researchers. In this study, we tried to define a methodology to assess the reproducibility and trueness of a quantitative SERS method and to compare different methods. In our opinion, this is a first important step toward a “standardization” process of SERS protocols, not proposed by a single laboratory but by a larger community.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | surface-enhanced raman spectroscopy; colloids; substrates; gold nanoparticles; silver nanoparticles; biomolecule detection; clinical diagnostics | ||||||||
| Subjects: | NATURAL SCIENCES > Chemistry > Physical Chemistry NATURAL SCIENCES > Chemistry > Analytic Chemistry NATURAL SCIENCES > Interdisciplinary Natural Sciences |
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| Divisions: | Division of Materials Physics | ||||||||
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| Depositing User: | Vlasta Mohaček Grošev | ||||||||
| Date Deposited: | 22 Oct 2020 06:32 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/5966 | ||||||||
| DOI: | 10.1021/acs.analchem.9b05658 |
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