Turčić, Petra; Bradamante, Mirna; Houra, Karlo; Štambuk, Nikola; Kelava, Tomislav; Konjevoda, Paško; Kazazić, Saša; Vikić-Topić, Dražen; Pokrić, Biserka (2009) Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice. Molecules, 14 (12). pp. 5017-5026. ISSN 1420-3049
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Abstract
Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the L and D-enantiomers of α-melanocortin peptide (α-MSH). The results showed that peptide enantiomerism is related to the protective effects of melanocortin peptides in vivo. L-α-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the opposite peptide configuration may be used to modulate its function and metabolism in vivo and in vitro.
| Item Type: | Article | ||||||||||||||||||||
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| Uncontrolled Keywords: | enantiomer ; α-MSH ; hepatoprotection ; hepatotoxicity ; antibody ; CD spectroscopy | ||||||||||||||||||||
| Subjects: | NATURAL SCIENCES > Chemistry | ||||||||||||||||||||
| Divisions: | Division of Molecular Medicine Division of Physical Chemistry NMR Center |
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| Depositing User: | Nikola Štambuk | ||||||||||||||||||||
| Date Deposited: | 06 Mar 2020 09:58 | ||||||||||||||||||||
| URI: | http://fulir.irb.hr/id/eprint/5325 | ||||||||||||||||||||
| DOI: | 10.3390/molecules14125017 |
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