Vazdar, Katarina; Jerić, Ivanka (2018) Amino-β-lactams in Ugi reaction: An efficient method for preparation of functionalized peptidomimetics. Tetrahedron, 74 (52). pp. 7495-7506. ISSN 0040-4020
Official URL: https://www.journals.elsevier.com/tetrahedron
Abstract
A synthetic strategy for the Ugi reaction on amino-β-lactam synthon 1 was developed. The Ugi reaction products 5 were obtained in satisfactory yields (47–78%) and generally, low diastereoselectivity (up to 72:28 dr). In case of Ugi products 5 derived from cyclohexylcarbaldehyde and amino-β-lactam 1, the reaction yields were lower (38–61%) but the products were obtained in high diastereoselectivity (>95:5).
| Item Type: | Article | ||||||||
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| Additional Information: | K.V. and I.J. thank the Croatian Science Foundation, Grant number 3102 for financial support. | ||||||||
| Uncontrolled Keywords: | Ugi reaction ; Amino-β-lactams ; Peptidomimetics | ||||||||
| Subjects: | NATURAL SCIENCES > Chemistry | ||||||||
| Divisions: | Division of Organic Chemistry and Biochemistry | ||||||||
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| Depositing User: | Ivanka Jerić | ||||||||
| Date Deposited: | 19 Nov 2019 12:47 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/5069 | ||||||||
| DOI: | 10.1016/j.tet.2018.11.028 |
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