Short overview on metabolomic approach and redox changes in psychiatric disorders

Nedić Erjavec, Gordana; Konjevod, Marcela; Nikolac Perković, Matea; Švob Štrac, Dubravka; Tudor, Lucija; Barbas, Coral; Grune, Tilman; Žarković, Neven; Pivac, Nela (2018) Short overview on metabolomic approach and redox changes in psychiatric disorders. Redox Biology, 14 . pp. 178-186. ISSN 2213-2317

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Abstract

Schizophrenia, depression and posttraumatic stress disorder (PTSD) are severe mental disorders and complicated diagnostic entities, due to their phenotypic, biological and genetic heterogeneity, unknown etiology, and poorly understood alterations in biological pathways and biological mechanisms. Disturbed homeostasis between overproduction of oxidant species, overcoming redox regulation and a lack of cellular antioxidant defenses, resulting in free radical-mediated pathology and subsequent neurotoxicity contributes to development of depression, schizophrenia and PTSD, their heterogeneous clinical presentation and resistance to treatment. Metabolomics is a discipline that combines different strategies with the aim to extract, detect, identify and quantify all metabolites that are present in a biological sample and might provide mechanistic insights into the etiology of various psychiatric disorders. Therefore, oxidative stress research combined with metabolomics might offer a novel approach in dissecting psychiatric disorders, since these data-driven but not necessarily hypothesis-driven methods might identify new targets, molecules and pathways responsible for development of schizophrenia, depression or PTSD. Findings from the oxidative research in psychiatry together with metabolomics data might facilitate development of specific and validated prognostic, therapeutic and clinical biomarkers. These methods might reveal bio- signatures of individual patients, leading to individualized treatment approach. In reviewing findings related to oxidative stress and metabolomics in selected psychiatric disorders, we have highlighted how these novel approaches might make a unique contribution to deeper understanding of psychopathological alterations underlying schizophrenia, depression and PTSD.

Item Type:	Article
Uncontrolled Keywords:	schizophrenia ; depression ; posttraumatic stress disorder ; oxidative stress ; lipid peroxidation ; metabolomics ; biomarkers
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Genomski i glikanski biomarkeri PTSP-a-GlycoGenePTSD Nela Pivac IP-2014-09-4289 HRZZ UNSPECIFIED UNSPECIFIED CRO_A-00033 UNSPECIFIED
Depositing User:	Gordana Nedić Erjavec
Date Deposited:	13 Nov 2018 14:43
URI:	http://fulir.irb.hr/id/eprint/4256
DOI:	10.1016/j.redox.2017.09.002

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