Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone

Šmidlehner, Tamara; Piantanida, Ivo (2017) Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone. Amino Acids, 49 (8). pp. 1381-1388. ISSN 0939-4451

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Abstract

One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also upon activation at the C-terminus. Two new compounds differing only in fluorophore-linker length showed exceptional fluorimetric and CD recognition between DS-RNA and DS-DNA, thus being promising beacons for versatile peptide incorporation.

Item Type:	Article
Uncontrolled Keywords:	fluorescent amino acid ; one-pot synthesis ; DNA/RNA recognition ; fluorescence ; CD
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima-DNA/RNA-MolSense Ivo Piantanida IP-2013-11-1477 HRZZ
Depositing User:	Ivo Piantanida
Date Deposited:	19 Nov 2018 09:43
URI:	http://fulir.irb.hr/id/eprint/4254
DOI:	10.1007/s00726-017-2438-x

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