Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model

Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra (2013) Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model. International Journal of Molecular Sciences, 14 (12). pp. 23654-23671. ISSN 1661-6596

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Abstract

The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.

Item Type:	Article
Uncontrolled Keywords:	colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect
Subjects:	NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Biology BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Imunoadjuvantno i zaštitno djelovanje propolisa u životinja Vesna Benković 119-0532265-1254 MZOS Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka Jasna Peter-Katalinić 335-0000000-3532 MZOS Molekularna obilježja miofibroblasta Dupuytrenove bolesti Krešimir Pavelić 335-0982464-2393 MZOS Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari Branka Zorc 006-0000000-3216 MZOS Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata Koraljka Gall-Trošelj 098-0982464-2511 MZOS Kemoprevencija rasta tumora polifenolnim sastavnicama Nada Oršolić 119-0000000-1255 MZOS
Depositing User:	Višnja StepaniÄ�
Date Deposited:	15 Jul 2016 09:07
URI:	http://fulir.irb.hr/id/eprint/2944
DOI:	10.3390/ijms141223654

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