Real-Time In Situ Powder X-ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals

Halasz, Ivan; Puškarić, Andreas; Kimber, Simon A.J.; Beldon, Patrick J.; Belenguer, Ana M.; Adams, Frank; Honkimäki, Veijo; Dinnebier, Robert E.; Patel, Bhavnita; Jones, William; Štrukil, Vjekoslav; Friščić, Tomislav (2013) Real-Time In Situ Powder X-ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals. Angewandte Chemie. International edition, 52 (44). pp. 11538-11541. ISSN 1433-7851

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Abstract

We have reported the first real-time, in situ X- ray diffraction study of mechanochemical synthesis and transformations of organic cocrystals. With time resolution in seconds, this technique allows the identification and monitoring of neat and liquid-assisted milling reactions, as well as in situ assessment of changes in the size of crystalline particles.

Item Type:	Article
Uncontrolled Keywords:	cocrystals; mechanochemistry; pharmaceutical materials; reaction monitoring; X-ray diffraction
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Materials Chemistry
Projects:	Project title Project leader Project code Project type Study of influence of aluminosilicte precursors on their transformations (Studij utjecaja svojstava alumosilikatnih prekursora na njihove transformacije)- Josip Bronić 098-0982904-2953 MZOS
Depositing User:	Andreas Puškarić
Date Deposited:	26 Jan 2016 13:11
URI:	http://fulir.irb.hr/id/eprint/2419
DOI:	10.1002/anie.201305928

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