Possible role of bacterial and viral infections in miscarriages

Matovina, Mihaela; Husnjak, Koraljka; Milutin Gašperov, Nina; Ciglar, Srećko; Grce, Magdalena (2004) Possible role of bacterial and viral infections in miscarriages. Fertility and Sterility, 81 (3). pp. 662-669. ISSN 0015-0282

| Request a personal copy from author

Preview

PDF - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (161kB) | Preview

Abstract

To determine the role of infections in miscarriages. Chorionic villi from aborted material were subjected to cytogenetic evaluation and analyzed for the presence of Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, human cytomegalovirus (HCMV), adeno-associated virus (AAV), and human papillomaviruses (HPV). Retrospective study. University hospital and academic research institution. Karyotyping and detection of bacterial and viral DNA by means of polymerase chain reaction (PCR) in placenta specimens. In 54 (50%) of 108 samples the karyotype was normal, in 38 (35%) samples it was abnormal, and in 16 (15%) samples karyotype was undetermined. No U. urealyticum, M. hominis, HCMV, or AAV-2 DNA was detected, while C. trachomatis DNA was detected in one (1%) and HPV DNA in eight (7%) samples. No significant correlation of HPV-positive findings with karyotype status was established. Our findings do not support a role of C. trachomatis, U. urealyticum, M. hominis, HCMV, or AAV infections in miscarriages during the first trimester of pregnancy. However, further investigation should be made to determine a possible involvement of HPVs in the development of genetic abnormalities of the fetus and in miscarriages.

Item Type:	Article
Uncontrolled Keywords:	miscarriage ; karyotyping ; placenta ; PCR ; bacterial infections ; viral infections
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Istraživanje uzroka, prevencija i liječenje infertiliteta Srećko Ciglar 0044008 UNSPECIFIED Molekularno-genetički i prognostički čimbenici u nastanku raka vrata maternice Magdalena Grce 0098104 UNSPECIFIED Određivanje globalnog genskog profila tumora metodom DNA-čipova Šime Spaventi 0101023 UNSPECIFIED
Depositing User:	Nina Milutin Gašperov
Date Deposited:	25 Nov 2015 09:54
URI:	http://fulir.irb.hr/id/eprint/2279

Actions (login required)

View Item