Human Papillomavirus, Cytomegalovirus and Adeno-associated Virus 2 Infections in Pregnant and Non-Pregnant Women with Cervical Intraepithelial Neoplasia

Grce, Magdalena; Husnjak, Koraljka; Matovina, Mihaela; Milutin Gašperov, Nina; Magdić, Lada; Husnjak, Ozren; Pavelić, Krešimir (2004) Human Papillomavirus, Cytomegalovirus and Adeno-associated Virus 2 Infections in Pregnant and Non-Pregnant Women with Cervical Intraepithelial Neoplasia. Journal of Clinical Microbiology, 42 (3). pp. 1341-1344. ISSN 0095-1137

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Abstract

Two hundred and eight cervical specimens from two groups of subjects, 165 non- and 53 pregnant women with CIN I-III were positive by PCR analyses for human papillomaviruses (HPVs), adeno-associated virus type 2 (AAV 2) and human cytomegalovirus (HCMV) in 67, 6 and 4.1% cases, respectively. The presence of AAV 2 infection was more frequently associated with pregnancy (17% versus 2.4%) and HPV-positive cervices (OR=6.358) than HCMV was. Increased HPV infection was strongly associated (P<0.001) with increased CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on the CIN development.

Item Type:	Article
Uncontrolled Keywords:	human papillomavirus; cytomegalovirus; adeno-associated virus type 2; cervical intraepithelial neoplasia
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Molekularno-genetički i prognostički čimbenici u nastanku raka vrata maternice Dr.sc. Magdalena Grce 0098104 UNSPECIFIED Određivanje globalnog genskog profila tumora metodom DNA-čipova Dr.sc. Šime Spaventi 0101023 UNSPECIFIED Utjecaj transdukcije gena/proteina na signalne puteve transformiranih stanica Dr.sc. Krešimir Pavelić 0098093 UNSPECIFIED
Depositing User:	Nina Milutin Gašperov
Date Deposited:	23 Nov 2015 15:48
URI:	http://fulir.irb.hr/id/eprint/2276
DOI:	10.1128/JCM.42.3.1341-1344.2004

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