Epigenetic activation of immune genes in cervical cancer

Milutin Gašperov, Nina; Farkas, Sanja A.; Nilsson, Torbjorn K.; Grce, Magdalena (2014) Epigenetic activation of immune genes in cervical cancer. Immunology Letters, 14 (S0165). pp. 1-2. ISSN 0165-2478

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Abstract

Immune system provides us protection from infectious pathogens and tumors formation during lifetime. Cervical cancer (CC), and its cause, human papillomavirus (HPV) are both challenges for the immune system. We present here evidence of epigenetic activation of immune system genes in CC. Illumina Infinium Human Methylation 450K BeadChip identified genes, which were all significantly hypomethylated in CC tissue versus normal tissue. The GeneMANIA computer program identified a tight network between those genes. The most strongly correlated genes based on their function are immune effectors' process (AIM2, BST2, BTN3A3, and IL12RB1) and response to virus related genes (AIM2, BST2, and IL12RB1). Thus, activation of those genes through demethylation is probably triggered by HPV oncogenes. In conclusion, the immune system of women who do not develop CC is probably activated earlier through DNA demethylation.

Item Type:	Article
Uncontrolled Keywords:	immune; cancer; HPV; gene; hypomethylation
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima) Magdalena Grce 098-0982464-2510 MZOS
Depositing User:	Nina Milutin Gašperov
Date Deposited:	23 Nov 2015 11:32
URI:	http://fulir.irb.hr/id/eprint/2275
DOI:	10.1016/j.imlet.2014.09.019

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