Mechanochemical Ritter reaction: a rapid approach to functionalized amides at room temperature

Dokli, Irena; Gredičak, Matija (2015) Mechanochemical Ritter reaction: a rapid approach to functionalized amides at room temperature. European Journal of Organic Chemistry, 2015 (12). pp. 2727-2732. ISSN 1434-193X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...

Abstract

A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment, utilizing a Brønsted acid catalyst. Its general application has been verified through a substrate screening investigation comprising a wide range of functionalized nitriles, as well as secondary and tertiary alcohols.

Item Type:

Article

Additional Information:

This is the accepted version of the following article: Mechanochemical Ritter Reaction: A Rapid Approach to Functionalized Amides at Room Temperature / Irena Dokli andMatija Gredičak, European journal of organic chemistry, 2015, 12; 2727-2732. which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201500051/abstract.

Uncontrolled Keywords:

mechanochemistry; organocatalysis; Ritter reaction; amides

Subjects:

NATURAL SCIENCES > Chemistry > Organic Chemistry

Divisions:

Division of Organic Chemistry and Biochemistry

Projects:

Project title	Project leader	Project code	Project type
Chemical transformations of natural compounds (Kemijske preobrazbe prirodnih spojeva)-	Lidija Varga-Defterdarović	098-0982933-2936	MZOS
Chiral building blocks for biological active molecules. Synthesis and reactivity (Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost)-	Zdenko Hameršak	098-0982933-2908	MZOS

Depositing User:

Matija Gredičak

Date Deposited:

28 Oct 2015 15:16

URI:

http://fulir.irb.hr/id/eprint/2198

DOI:

10.1002/ejoc.201500051