Fusion leads to effective segregation of damage during cell division: An analytical treatment

Lade, Steven J.; Coelho, Miguel; Tolić, Iva Marija; Gross, Thilo (2015) Fusion leads to effective segregation of damage during cell division: An analytical treatment. Journal of Theoretical Biology, 378 . pp. 47-55. ISSN 0022-5193

| Request a personal copy from author

Abstract

High levels of cellular damage are associated with impairment of cellular function and cell death. Partitioning the damage into a fraction of cells in the population improves population fitness and survival. We have previously shown that protein aggregates, resulting from misfolded, damaged proteins, fuse with each other leading to damage partitioning during cell division. Here, using an analytical treatment of aggregate fusion in dividing cells we present analytical expressions for two measures of damage partition: aggregate mass partition asymmetry between two dividing cells and standard deviation of total aggregate mass across the population. The scaling laws obtained demonstrate how damage partition may generally depend on characteristics of the cellular processes, facilitating better understanding of damage segregation in biological cells.

Item Type:	Article
Uncontrolled Keywords:	Aggregation; Damage partition; Van Kampen expansion; Directed transport
Subjects:	NATURAL SCIENCES > Physics > Biophysics and Medical Physics NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions:	Division of Molecular Biology
Depositing User:	Patrik Risteski
Date Deposited:	26 Oct 2015 07:48
URI:	http://fulir.irb.hr/id/eprint/2170
DOI:	10.1016/j.jtbi.2015.04.022

Actions (login required)

View Item