Mannose 6-phosphate/insulin-like growth factor 2 receptor in carcinogenesis

Martin-Kleiner, Irena; Gall Trošelj, Koraljka (2010) Mannose 6-phosphate/insulin-like growth factor 2 receptor in carcinogenesis. Cancer letters, 289 (1). pp. 11-22. ISSN 0304-3835

Preview

PDF - Accepted Version - article Download (394kB) | Preview

Abstract

The cation independent mannose 6-phosphate/insulin-like growth factor 2 (M6P/IGF2R) is a multifunctional receptor. It is included in a variety of cellular processes which become disregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.

Item Type:	Article
Uncontrolled Keywords:	mannose 6-phosphate/insulin-like growth factor 2 receptor; LOH; mutation; cancer
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata- Koraljka Gall-Trošelj 098-0982464-2511 MZOS
Depositing User:	Irena Martin Kleiner
Date Deposited:	22 Dec 2016 16:42
URI:	http://fulir.irb.hr/id/eprint/1979
DOI:	10.1016/j.canlet.2009.06.036

Actions (login required)

View Item