Vrdoljak, Višnja; Đilović, Ivica; Rubčić, Mirta; Kraljević Pavelić, Sandra; Kralj, Marijeta; Matković-Čalogović, Dubravka; Piantanida, Ivo; Novak, Predrag; Rožman, Andrea; Cindrić, Marina (2010) Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity. European Journal of Medicinal Chemistry, 45 (1). pp. 38-48. ISSN 0223-5234
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Abstract
New dioxomolybdenum(VI) complexes were obtained by the reaction of [MoO2(acac)2] with thiosemicarbazone ligands derived from 3-thiosemicarbazide and 4-(diethylamino)salicylaldehyde (H2L1), 2-hydroxy-3-methoxybenzaldehyde (H2L2) or 2-hydroxy-1-naphthaldehyde (H2L3). In all complexes thiosemicarbazonato ligands are coordinated to molybdenum as tridentate ONS-donors. Octahedral coordination of each molybdenum atom is completed by methanol molecule (in 1a-3a) or by oxygen atom of Mo=O unit from the neighbouring molecule (in 1-3). All complexes were characterized by means of chemical analyses, IR spectroscopy, TG and NMR measurements. The molecular structures of the ligand H2L2 and complex [MoO2L2(CH3OH)]• CH3OH (2a) have been determined by single crystal X-ray crystallography. The characterisation of thiosemicarbazonato molybdenum(VI) complexes (1-4) as well as of the 4-phenylthisemicarbazonato molybdenum(VI) complexes (5-8) in aqueous medium revealed that upon dissolving complexes in water, most likely to some extent dissociation took place, although experimental data didn’ t allow exact quantification of dissociation. The antiproliferative effects of studied molybdenum(VI) complexes (1-8) on the human cell lines were identical to the activity of their corresponding ligands.
| Item Type: | Article | ||||||||||||||||||||||||
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| Uncontrolled Keywords: | thiosemicarbazone, molybdenum(VI) complexes, X-ray crystal structures, antiproliferative effects, tumour cell lines | ||||||||||||||||||||||||
| Subjects: | NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences |
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| Divisions: | Division of Organic Chemistry and Biochemistry | ||||||||||||||||||||||||
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| Depositing User: | Ivo Piantanida | ||||||||||||||||||||||||
| Date Deposited: | 14 Nov 2014 07:58 | ||||||||||||||||||||||||
| URI: | http://fulir.irb.hr/id/eprint/1624 | ||||||||||||||||||||||||
| DOI: | 10.1016/j.ejmech.2009.09.021 |
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