Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Sornosa-Ten, Alejandra; Albelda, M. Teresa; Frías, Juan C.; García-España, Enrique; Llinares, José M.; Budimir, Ana; Piantanida, Ivo (2010) Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids. Organic and Biomolecular Chemistry, 8 (11). pp. 2567-2574. ISSN 1477-0520

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Abstract

Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.

Item Type:	Article
Uncontrolled Keywords:	tripodal polyamines; DNA and RNA interactions; RNA selectivity; nucleotides
Subjects:	NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima [202026] Ivo Piantanida 098-0982914-2918 MZOS
Depositing User:	Ivo Piantanida
Date Deposited:	14 Nov 2014 10:28
URI:	http://fulir.irb.hr/id/eprint/1622
DOI:	10.1039/c000124d

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