Babić Leko, Mirjana; Jurasović, Jasna; Nikolac Perković, Matea; Španić, Ena; Sekovanić, Ankica; Orct, Tatjana; Lukinović Škudar, Vesna; Bačić Baronica, Koraljka; Kiđemet-Piskač, Spomenka; Vogrinc, Željka; Pivac, Nela; Borovečki, Fran; Hof, Patrick R.; Šimić, Goran (2021) The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease. Journal of Alzheimer's Disease, 82 (2). pp. 661-672. ISSN 1387-2877
![[img]](http://fulir.irb.hr/style/images/fileicons/application_pdf.png) |
PDF
- Accepted Version
- article
Available under License Creative Commons Attribution. Download (930kB) |
Abstract
Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. Objective: To test the association of essential metals with APOE genotype. Methods: We compared plasma and cerebrospinal fluid (CSF) levels of copper, zinc, iron, sodium, magnesium, calcium, cobalt, molybdenum, manganese, boron, and chromium, and CSF ferritin levels among AD, mild cognitive impairment (MCI) patients, and healthy controls (HC) with different APOE genotype. Results: Sodium, copper, and magnesium levels were increased in carriers of ɛ4 allele. Additionally, the increase in sodium, calcium and cobalt plasma levels was observed in carriers of ɛ4/ɛx genotype. The decrease in boron plasma levels was observed in carriers of ɛ4 allele and ɛ4/ɛ4 genotype. Additionally, CSF zinc levels as well as plasma sodium levels were increased in AD patients compared to HC. Conclusion: These results indicate that the molecular underpinnings of association of essential metals and metalloids with APOE should be further tested and clarified in vivo and in vitro.
| Item Type: | Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Uncontrolled Keywords: | Alzheimer’s disease; apolipoprotein E; copper; metals; mild cognitive impairment; zinc | ||||||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences SOCIAL SCIENCES SOCIAL SCIENCES > Psychology HUMANISTIC SCIENCES |
||||||||||||
| Divisions: | Division of Molecular Medicine | ||||||||||||
| Projects: |
|
||||||||||||
| Depositing User: | Virna Brumnić | ||||||||||||
| Date Deposited: | 17 Apr 2026 07:46 | ||||||||||||
| URI: | http://fulir.irb.hr/id/eprint/11747 | ||||||||||||
| DOI: | 10.3233/JAD-210158 |
Actions (login required)
 |
View Item |
Altmetric
Altmetric
