The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats

Vukšić, Antonija; Rašić, Dubravka; Žunec, Suzana; Božina, Tamara; Konjevoda, Paško; Lovrić, Jasna; Bilušić, Marinko; Bradamante, Vlasta (2023) The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats. Archives of Industrial Hygiene and Toxicology, 74 (1). pp. 34-41. ISSN 1848-6312

PDF - Published Version - article Available under License Creative Commons Attribution. Download (282kB)

Abstract

The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats. Normolipidaemic (Wistar) rats were receiving 10 or 50 mg/kg a day of simvastatin or 30 or 50 mg/kg a day of fenofibrate. Hyperlipidaemic (Zucker) rats were receiving 50 mg/kg/day of simvastatin or 30 mg/kg/day of fenofibrate. Control normolipidaemic and hyperlipidaemic rats were receiving saline. Simvastatin, fenofibrate, and saline were administered by gavage for three weeks. In normolipidaemic rats simvastatin and fenofibrate showed similar and dose-independent effects on plasma and brain MDA and GSH concentrations. Generally, plasma and brain MDA decreased, while brain GSH concentration increased. In hyperlipidaemic rats simvastatin did not affect plasma and brain MDA and GSH concentrations but significantly decreased liver GSH. Fenofibrate decreased plasma and liver MDA but increased brain MDA. In both rat strains fenofibrate significantly decreased liver GSH concentrations, most likely because fenofibrate metabolites bind to GSH. Our findings suggest that simvastatin acts as an antioxidant only in normolipidaemic rats, whereas fenofibrate acts as an antioxidant in both rat strains.

Item Type:	Article
Uncontrolled Keywords:	lipid peroxidation; lipid-lowering drugs; oxidative stress; Wistar rats; Zucker rats
Subjects:	NATURAL SCIENCES
Divisions:	NMR Center
Projects:	Project title Project leader Project code Project type Serumske esteraze, leptin, lipidi i antilipidni lijekovi- Vlasta Bradamante 108-0000000-0013 MZOS
Depositing User:	Josipa Karadžole
Date Deposited:	13 Apr 2026 13:01
URI:	http://fulir.irb.hr/id/eprint/11676
DOI:	10.2478/aiht-2023-74-3697

Actions (login required)

View Item