Antifungal Effect of Polymethyl Methacrylate Resin Base with Embedded Au Nanoparticles

Marić, Ivan; Zore, Anamarija; Rojko, Franc; Škapin, Andrijana Sever; Štukelj, Roman; Učakar, Aleksander; Vidrih, Rajko; Veselinović, Valentina; Gotić, Marijan; Bohinc, Klemen (2023) Antifungal Effect of Polymethyl Methacrylate Resin Base with Embedded Au Nanoparticles. Nanomaterials, 13 (14). ISSN 2079-4991

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Abstract

Full and partial restorations in dentistry must replicate the characteristics of the patient’s natural teeth. Materials must have good mechanical properties and be non-toxic and biocompatible. Microbes, which can form biofilms, are constantly in contact with restorations. In this study, we investigate how well Candida albicans adheres to a polymethyl methacrylate (PMMA) resin base with gold (Au) nanoparticles. We synthesized Au nanoparticles and characterized them. The average size of Au nanoparticles embedded in PMMA was 11 nm. The color difference ΔE between PMMA and PMMA/Au composites was 2.7 and was still esthetically acceptable to patients. PMMA/Au surfaces are smoother and more hydrophilic than pure PMMA surfaces, and the isoelectric point of both types of surfaces was 4.3. Above the isoelectric point, PMMA/Au surfaces are more negatively charged than PMMA surfaces. The added Au nanoparticles decreased the tensile strength, while the hardness did not change significantly. Adhesion measurements showed that PMMA surfaces modified with Au nanoparticles reduced the extent of microbial adhesion of Candida albicans.

Item Type:	Article
Uncontrolled Keywords:	fungal adhesion; C. albicans; polymethyl methacrylate resin; Au; surface properties; composites
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Materials Chemistry Division of Materials Physics
Depositing User:	Josipa Karadžole
Date Deposited:	25 Mar 2026 10:37
URI:	http://fulir.irb.hr/id/eprint/11465
DOI:	10.3390/nano13142128

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