Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle

Starešinić, Mario; Japjec, Mladen; Vraneš, Hrvoje; Prtorić, Andreja; Žižek, Helena; Krezić, Ivan; Gojković, Slaven; Smoday, Ivan Maria; Oroz, Katarina; Starešinić, Eva; Dretar, Vilim; Yago, Haidi; Milavić, Marija; Sikirić, Sunčana; Lovrić, Eva; Batelja Vuletić, Lovorka; Simeon, Paris; Dobrić, Ivan; Štrbe, Sanja; Kokot, Antonio; Vlainić, Josipa; Blagaić, Alenka Boban; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag (2022) Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. Biomedicines, 10 (12). ISSN 2227-9059

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Abstract

First, we review the definitively severed myotendinous junction and recovery by the cytoprotective stable gastric pentadecapeptide BPC 157 therapy, its healing that might combine both transected and detached tendon and transected muscle, ligament and bone injuries, applied alone, as native peptide therapy, effective in rat injury, given intraperitoneally or in drinking water or topically, at the site of injury. As a follow up, we reviewed that with the BPC 157 therapy, its cytoprotective ability to organize simultaneous healing of different tissues of and full recovery of the myotendinous junction might represent the particular muscle therapy against distinctive etiopathology muscle disabilities and weakness. In this, BPC 157 therapy might recover many of muscle disabilities (i.e., succinylcholine, vascular occlusion, spinal cord compression, stroke, traumatic brain injury, severe electrolyte disturbances, neurotoxins, neuroleptics, alcohol, serotonin syndrome and NO-system blockade and tumor-cachexia). These might provide practical realization of the multimodal muscle-axis impact able to react depending on the condition and the given agent(s) and the symptoms distinctively related to the prime injurious cause symptoms in the wide healing concept, the concept of cytoprotection, in particular. Further, the BPC 157 therapy might be the recovery for the disabled heart functioning, and disabled smooth muscle functioning (various sphincters function recovery). Finally, BPC 157, native and stable in human gastric juice, might be a prototype of anti-ulcer cytoprotective peptide for the muscle therapy with high curing potential (very safe profile (lethal dose not achieved), with suited wide effective range (mu g-ng regimens) and ways of application).

Item Type:	Article
Uncontrolled Keywords:	stable gastric pentadecapeptide BPC 157; muscle healing; therapy
Subjects:	BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Virna Brumnić
Date Deposited:	23 Mar 2026 12:42
URI:	http://fulir.irb.hr/id/eprint/11402
DOI:	10.3390/biomedicines10123221

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