Enediyne-Comprising Amino Aldehydes in the Passerini Reaction

Glavaš, Mladena; Gredičak, Matija; Jerić, Ivanka (2018) Enediyne-Comprising Amino Aldehydes in the Passerini Reaction. ACS Combinatorial Science, 20 (3). pp. 151-155. ISSN 2156-8944

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Abstract

Multicomponent reactions represent a highly efficient approach to a broad spectrum of structurally diverse compounds starting from simple and affordable compounds. A focused library of tweezers-like compounds is prepared by employing the multicomponent Passerini reaction comprising enediyne-derived amino aldehydes. The reaction proceeds under mild conditions yielding Passerini products in good to excellent yields. Postcondensation modifications of Passerini products are demonstrated through a simple deprotection/coupling approach comprising amino functionality, furnishing enediyne cores with highly decorated arms.

Item Type:	Article
Additional Information:	This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Combinatorial Science, copyright ©2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscombsci.7b00167
Uncontrolled Keywords:	multicomponent reactions; enediynes; Passerini reaction; receptors
Subjects:	NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry NMR Center
Projects:	Project title Project leader Project code Project type Višekomponentne reakcije u sintezi peptidnih mimetika-MIMICRy Ivanka Jerić IP-2014-09-3102 HRZZ
Depositing User:	Mladena Glavaš
Date Deposited:	17 Dec 2025 09:11
URI:	http://fulir.irb.hr/id/eprint/10562
DOI:	10.1021/acscombsci.7b00167

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