Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications

Debeljak, Željko; Begolli, Gramos; Marković, Ivana; Knežević, Jelena (2023) Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications. Biochemia medica, 33 (3). pp. 255-265. ISSN 13300962

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Abstract

Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords “carbohydrate sulfotransferase” together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of CHST3 gene cause skeletal dysplasia, chondrodysplasia, and autosomal recessive multiple joint dislocations while increased tissue expression of CHST11, CHST12 and CHST15 is an unfavourable prognostic factor in ovarian cancer, glioblastoma and pancreatic cancer, respectively. Recently, CHST11 and CHST15 overexpression in the vascular smooth muscle cells was linked to the severe lung pathology in COVID-19 patients. Promising CHST diagnostic and prognostic applications have been described but larger clinical studies and robust analytical procedures are required for the more reliable diagnostic performance estimations.

Item Type:	Article
Uncontrolled Keywords:	cancer; carbohydrate sulfotransferases; connective tissue; inflammation; tumour markers
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Molecular Medicine
Depositing User:	Josipa Karadžole
Date Deposited:	07 Nov 2025 14:39
URI:	http://fulir.irb.hr/id/eprint/10182
DOI:	10.11613/bm.2023.030503

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