A Design of Copper(II) Coordination Polymers with l-Homoserine: Structural, Spectroscopic, and Biological Studies

Vušak, Darko; Kekez, Ivana; Kučera-Čavara, David; Jurec, Jurica; Žilić, Dijana; Šimunović Letić, Marta; Horvatić, Elena; Mioč, Marija; Galić, Nives; Prugovečki, Biserka (2025) A Design of Copper(II) Coordination Polymers with l-Homoserine: Structural, Spectroscopic, and Biological Studies. ACS Omega, 10 (39). pp. 45571-45584. ISSN 2470-1343

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Abstract

Five copper(II) coordination polymers trans-[Cu(μ-L-hser)-(L-hser)]n (1a), {cis-[Cu(μ-L-hser)2]·H2O}n (1b·H2O), {[Cu(μ-L-hser)-(H2O)(bpy)]2SO4·2H2O}n (2·2H2O), {[Cu(μ-L-hser)(H2O)(bpy)]2SO4·3H2O}n (2·3H2O), and {[Cu(μ-L-hser)(H2O)(bpy)]2SO4·4H2O}n (2·4H2O)�were synthesized via solution-based and/or mechanochemical methods (L-hser = L-homoserinate, bpy = 2,2’-bipyridine). The compounds were characterized in the solid state (using single-crystal and powder X-ray diffraction (SCXRD and PXRD), EPR, Raman and IR spectroscopy, and thermogravimetric analysis (TGA)) and in solution (using UV−vis spectroscopy, EPR, Raman spectroscopy, and fluorimetry). In the binary bis(homoserinato)copper(II) compounds, 1a and 1b·H2O, polymerization is achieved through the hydroxyl group of the L-homoserinate side chain. In contrast, all ternary compounds (2·2H2O, 2·3H2O, and 2·4H2O) achieved polymerization through the carboxylate group of L-homoserinate. Successful solid-state transformation of 2·2H2O into 2·4H2O was established at higher relative humidity values. Copper(II) centers adopt a square-pyramidal geometry in 1a and a distorted octahedral geometry in all other investigated compounds. Spectroscopic studies suggest that 1a retains its solid-state geometry in solution, while 2·2H2O and 2·3H2O exhibit slight changes. Among the compounds, 2·2H2O exhibited moderate antiproliferative activity against H460 (lung), MCF-7 (breast), and HCT116 (colon) cancer cell lines, and demonstrated antibacterial activity against Moraxella catarrhalis ATCC 23246. Absorption and fluorescence spectra suggested a lower binding affinity of 2·2H2O to the doublestranded DNA dodecamer ds(CGCGAATTCGCG).

Item Type:	Article
Uncontrolled Keywords:	antiproliferative and antibacterial activity; coordination polymers; copper(II); L-homoserine; 2.2'-bipyridine
Subjects:	NATURAL SCIENCES
Divisions:	Division of Molecular Medicine Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Molekulski magnetizam u naprednim čvrstim i mekim materijalima Dijana Žilić IP-2022-10-9292 Znanstveno-istraživački projekti Priprava, karakterizacija i biokompatibilnost novih supramolekulskih kompleksa lijek/ciklodekstrin i lijek/dekstrinske nanospužve s poboljšanim svojstvima Nives Galić IP-2022-10-6033 Znanstveno-istraživački projekti Centar izvrsnosti u kemiji - CIuK-CIuK Josip Požar; Mirta Rubčić; Ivana Biljan KK.01.1.1.02.0016 Infrastrukturni projekti Sinteza i strukturna karakterizacija organskih i kompleksnih spojeva; struktura proteina Biserka Prugovečki UNSPECIFIED Znanstveno-istraživački projekti
Depositing User:	Ana Zečević
Date Deposited:	06 Nov 2025 07:59
URI:	http://fulir.irb.hr/id/eprint/10155
DOI:	10.1021/acsomega.5c05776

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