Kontrec, Darko; Jurin, Mladenka; Jakas, Andreja; Roje, Marin (2024) New Levan-Based Chiral Stationary Phases: Synthesis and Comparative HPLC Enantioseparation of (±)-trans-β-Lactam Ureas in the Polar Organic Mode. Molecules, 29 (10). ISSN 1420-3049
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Abstract
In this paper, the preparation of three new polysaccharide-type chiral stationary phases (CSPs) based on levan carbamates (3,5-dimethylphenyl, 4-methylphenyl, and 1-naphthyl) is described. The enantioseparation of (±)-trans-β-lactam ureas 1a–h was investigated by high-performance liquid chromatography (HPLC) on six different chiral columns (Chiralpak AD-3, Chiralcel OD-3, Chirallica PST-7, Chirallica PST-8, Chirallica PST-9, and Chirallica PST-10) in the polar organic mode, using pure methanol (MeOH), ethanol (EtOH), and acetonitrile (ACN). Apart from the Chirallica PST-9 column (based on levan tris(1-naphthylcarbamate), the columns exhibited a satisfactory chiral recognition ability for the tested trans-β-lactam ureas 1a–h.
Item Type: | Article | ||||||||
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Uncontrolled Keywords: | levan; trans-β-lactam ureas; chiral separation; enantioselective HPLC; polar organic mode; polysaccharide-type chiral stationary phases; CSPs; new chiral material | ||||||||
Subjects: | NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology |
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Divisions: | Division of Organic Chemistry and Biochemistry | ||||||||
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Depositing User: | Ivana Vuglec | ||||||||
Date Deposited: | 17 Oct 2025 09:18 | ||||||||
URI: | http://fulir.irb.hr/id/eprint/10005 | ||||||||
DOI: | 10.3390/molecules29102213 |
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