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Overview of Clinical Relevance of Antibodies Against Oxidized Low-Density Lipoprotein (oLAb) Within Three Decades by ELISA Technology

Wonisch, Willibald; Tatzber, Franz; Lindschinger, Meinrad; Falk, Andreas; Resch, Ulrike; Mörkl, Sabrina; Žarković, Neven; Cvirn, Gerhard (2024) Overview of Clinical Relevance of Antibodies Against Oxidized Low-Density Lipoprotein (oLAb) Within Three Decades by ELISA Technology. Antioxidants, 13 (12). ISSN 2076-3921

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Abstract

One of the most prominent actions of oxidative stress is the attack of free radicals on poylyunsaturated fatty acids (PUFAs), initiating a chain reaction to modify these PUFAs and generate oxidized modifications on all biomolecules. In the last quarter of the 20th century, intensive research was carried out to identify antibodies against such modifications. In the mid-1990s, the first enzyme-linked immunosorbent assay (ELISA) was introduced to the market, significantly accelerating research activities and knowledge gain. During this pioneering period, the main focus was on cardiovascular diseases, cancer, diabetes, and other diseases associated with oxidative stress. Subsequently, a standard range of these antibodies against oxidized LDL (oLAb) was determined in the population. Furthermore, the impact of exhaustive physical activity and diet on oLAb titers, and the correlation between newborns and mothers after delivery, as well as nutritional intake in newborns, were evaluated. Subsequently, the harmful effects of smoking and many other areas regarding oLAb titer were published, resulting in novel approaches for prognostic and therapeutic options, in particular through studies with antioxidants, which were able to influence oLAb significantly. This review presents an overview of the research activities obtained with this ELISA over the past three decades.

Item Type: Article
Uncontrolled Keywords: antibody against oxidized LDL; ELISA; antioxidants; oxidative stress; lipid peroxidation
Subjects: NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
BIOMEDICINE AND HEALTHCARE > Pharmacy > Pharmacy
BIOTECHNICAL SCIENCES > Food Technology
Divisions: Division of Molecular Medicine
Depositing User: Ivana Vuglec
Date Deposited: 13 Oct 2025 08:21
URI: http://fulir.irb.hr/id/eprint/9980
DOI: 10.3390/antiox13121560

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