hrvatski jezikClear Cookie - decide language by browser settings

Serotonin System in the Human Placenta – the Knowns and Unknowns

Perić, Maja; Bečeheli, Ivona; Čičin-Šain, Lipa; Desoye, Gernot; Štefulj, Jasminka (2022) Serotonin System in the Human Placenta – the Knowns and Unknowns. Frontiers in endocrinology (Lausanne), 13 . ISSN 1664-2392

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (2MB) | Preview


The biogenic monoamine serotonin (5- hydroxytryptamine, 5-HT) is a chemical messenger widely distributed in the brain and various other organs. Its homeostasis is maintained by the coordinated activity of a variety of proteins, including enzymes of serotonin metabolism, transmembrane transporters of serotonin, and serotonin receptors. The serotonin system has been identified also in the placenta in rodent models as a key component of placental physiology. However, serotonin pathways in the human placenta are far from well understood. Their alterations may have long-lasting consequences for the fetus that can manifest later in life. In this review, we summarize information on the location of the components of the serotonin system in the human placenta, their regulation, function, and alterations in pathological pregnancies. We highlight current controversies and discuss important topics for future research.

Item Type: Article
Uncontrolled Keywords: human placenta ; pregnancy ; serotonin ; serotonin receptors ; serotonin transporters ; MAO ; TPH ; fetal sex
Subjects: NATURAL SCIENCES > Biology
NATURAL SCIENCES > Interdisciplinary Natural Sciences
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteinaŠtefulj, JasminkaIP-2018-01-6547HRZZ
Depositing User: Maja Perić
Date Deposited: 06 Apr 2023 10:58
DOI: 10.3389/fendo.2022.1061317

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font