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Differential expression and evolutionary signatures of Borrelia burgdorferi morphotypes

Čorak, Nina (2022) Differential expression and evolutionary signatures of Borrelia burgdorferi morphotypes. Doctoral thesis, Institute Ruđer Bošković.

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In laboratory conditions, Borrelia burgdorferi, the causative agent of Lyme disease, exists as a spirochete, round body, bleb, or biofilm culture. This doctoral thesis suggests that spirochete to round body transition relies on the delicate regulation of a relatively small number of evolutionary conserved genes. In contrast, spirochete to bleb and biofilm transition includes significant reshaping of transcription profiles towards evolutionary young genes.

Item Type: Thesis (Doctoral thesis)
Uncontrolled Keywords: Borrelia burgdorferi ; Lyme disease ; Differential expression ; Bacterial morphotypes ; Morphological plasticity ;Genomic phylostratigraphy
Subjects: NATURAL SCIENCES > Biology > Microbiology
Divisions: Division of Molecular Biology
Project titleProject leaderProject codeProject type
Filostratigrafija nastanka i gubitka gena-PhyLossTomislav Domazet-LošoIP-2016-06-5924HRZZ
Depositing User: Nina Čorak
Date Deposited: 05 Oct 2022 08:23

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