Čorak, Nina (2022) Differential expression and evolutionary signatures of Borrelia burgdorferi morphotypes. Doctoral thesis, Institute Ruđer Bošković.
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Abstract
In laboratory conditions, Borrelia burgdorferi, the causative agent of Lyme disease, exists as a spirochete, round body, bleb, or biofilm culture. This doctoral thesis suggests that spirochete to round body transition relies on the delicate regulation of a relatively small number of evolutionary conserved genes. In contrast, spirochete to bleb and biofilm transition includes significant reshaping of transcription profiles towards evolutionary young genes.
| Item Type: | Thesis (Doctoral thesis) | ||||||||
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| Uncontrolled Keywords: | Borrelia burgdorferi ; Lyme disease ; Differential expression ; Bacterial morphotypes ; Morphological plasticity ;Genomic phylostratigraphy | ||||||||
| Subjects: | NATURAL SCIENCES > Biology > Microbiology | ||||||||
| Divisions: | Division of Molecular Biology | ||||||||
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| Depositing User: | Nina Čorak | ||||||||
| Date Deposited: | 05 Oct 2022 08:23 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/7544 |
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