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Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction

Beriša, Arben; Glavač, Danijel; Zheng, Chao; You, Shu-Li; Gredičak, Matija (2022) Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction. Organic Chemistry Frontiers, 9 . pp. 428-435. ISSN 2052-4110

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Abstract

An efficient enantioselective formal Betti reaction between phenols and diaryl ketimines generated in situ from isoindolinone alcohols is described. In a reaction catalyzed by a chiral phosphoric acid, a broad range of ketimines and phenols afforded isoindolinone derivatives comprising a congested quaternary stereogenic center bearing three aryl groups in high yields, and high regioselectivities and enantioselectivities.

Item Type: Article
Uncontrolled Keywords: three aryl groups ; Betti reaction
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Nove strategije za pripravu tetrasupstituiranih kiralnih centara: asimetrične katalitičke reakcije usmjerene protuanionom-NSYNC-ACDCMatija GredičakIP-2018-01-4053HRZZ
Depositing User: Matija Gredičak
Date Deposited: 31 Mar 2022 11:35
URI: http://fulir.irb.hr/id/eprint/7135
DOI: 10.1039/d1qo01684a

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