hrvatski jezikClear Cookie - decide language by browser settings

Post-Translational Modifications That Drive Prostate Cancer Progression

Samaržija, Ivana (2021) Post-Translational Modifications That Drive Prostate Cancer Progression. Biomolecules, 11 (2). ISSN 2218-273X

PDF - Published Version - article
Available under License Creative Commons Attribution.

Download (4MB) | Preview


While a protein primary structure is determined by genetic code, its specific functional form is mostly achieved in a dynamic interplay that includes actions of many enzymes involved in post- translational modifications. This versatile repertoire is widely used by cells to direct their response to external stimuli, regulate transcription and protein localization and to keep proteostasis. Herein, post-translational modifications with evident potency to drive prostate cancer are explored. A comprehensive list of proteome-wide and single protein post- translational modifications and their involvement in phenotypic outcomes is presented. Specifically, the data on phosphorylation, glycosylation, ubiquitination, SUMOylation, acetylation, and lipidation in prostate cancer and the enzymes involved are collected. This type of knowledge is especially valuable in cases when cancer cells do not differ in the expression or mutational status of a protein, but its differential activity is regulated on the level of post-translational modifications. Since their driving roles in prostate cancer, post-translational modifications are widely studied in attempts to advance prostate cancer treatment. Current strategies that exploit the potential of post-translational modifications in prostate cancer therapy are presented.

Item Type: Article
Uncontrolled Keywords: SUMOylation ; acetylation ; glycosylation ; lipidation ; phosphorylation ; post-translational modification ; prostate cancer ; ubiquitination
Divisions: Division of Molecular Medicine
Depositing User: Lovorka Čaja
Date Deposited: 29 Mar 2022 09:35

Actions (login required)

View Item View Item


Downloads per month over past year

Increase Font
Decrease Font
Dyslexic Font